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Innovation
TimoD
A non-biodegradable intra-ocular implant delivering precise controlled dose of timolol in the eye.
Aimed to:
Reduce intra-ocular pressure and treat adult patients with primary open-angle glaucoma or ocular hypertension.
Strongly increase patient compliance and lower patient burden of daily medicating by removing undesirable side effects tied to the drug.
Designed for minimum 2 years duration approval.
Single intra-ocular implant in the shape of a flexible ring.
Delivery of drugs close to action site provides an impressive reduction of dose and side effects (no drug systemic passage) compared to eye drops.
Implantation:
With a specific injector (preloaded).
Minimally invasive surgery mimicked on a cataract surgery (possible at the same time).
Duration: 15 minutes in a one-day clinic visit.
Development phase: early clinical stage (FIH planned Q4 2021)
Preclinical phase results:
Absence of timolol in blood (so no systemic side effects).
Local release at the site of action.
GLP safety study of 6 months showed excellent implant tolerance.
Design and composition defined for Phase I.
Next step: First in human planned end 2021.
Development Stage
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